Cialis is a medicine that was produced in order to treat the problem of impotence or erectile dysfunction. Most of the patients suffering from erectile dysfunction have preferred using Cialis as their first choice due to substance called Tadalafil that is present in Cialis and it was approved by FDA in 2003, novembre. Cialis is produced by Eli Lilly and Company, and it contains the success ratio of 78% which allows the males to engage in extremely successful sexual intercourse. The main property which makes Cialis unique is that patients who are suffering from any other medical condition can also use this medicine with having any side effects unlike any other impotence treating medicine.

Just like any other medicine for treating the impotence problem, Cialis is formulated in order to provide multiple benefits while engaging in any sexual activity. These benefits include powerful and stable erection for longer time, hardest erection, multiple chances of achieving orgasms, and the level of consummation and pleasure is maximized.

Correct way to consume Cialis

Similar to any other medicine in the world, Cialis must be taken with complete precautions and guidance otherwise the users might face difficulties. Our recommendation is that prior to consuming Cialis, you must first consult any doctor or physician and share your complete medical history with them so that they can guide you properly about how should you consume Cialis. Sharing complete medical history with doctor is highly recommended because sometimes reaction or allergies could be faced.

La maggior parte delle volte, Cialis is consumed by eating through mouth. Eating with food is not necessary. The best way to take Cialis is the way that the doctor has suggested. Basically there are two ways in which Cialis can be taken. It can either be taken once in a day daily or only taken when you are planning to engage in any sexual activity. If the individual is planning to take Cialis every day then they must take low dose of 2.5-5mg in a day. The advantage of having Cialis every day is that the individual can engage in sexual activity at any time of the day because the effect of Cialis starts to finish off after 36 ore.

If the individual is planning to take Cialis only when they are willing to engage in an intercourse then they must take higher dose. The best and effective way to take Cialis when needed is to take thirty minutes before engaging and must be taken once a day otherwise there might be some side effects.

Mistakes of taking Cialis with other things

Grapefruit is one of the most important fruit that should be avoided taken simultaneously with Cialis. Grapefruit can increased the amount of Cialis in the blood flow by huge margin that could result in some dangerous side effects.

If Cialis is consumed simultaneously with any other medicines that contains nitrates then they might escalate the heart rate and reduce the blood pressure. This could cause severe heart pains or in some cases heart attacks.

There are some drugs or medicines that are taken in order to maintain the blood pressure level that consists terazosin. If you are willing to take Cialis with any of this drug then you must take lower dose.

If Cialis is taken simultaneously with any alcoholic drink then the blood pressure level would be reduced to a great extent which is very dangerous for the individual.

Cialis must never be taken with any other drug or medicine that contains Tadalafil in them. This could lead to overindulge of Cialis which is very dangerous and lethal for the individual.

Tadalafil is rapidly absorbed when taken orally. After ingestion of a single dose Tmax ranges from 30 min to 6 h (average 2 ore), the absolute bioavailability not determined. The rate and extent of absorption do not depend on food intake.Middle seeming volume of distribution after a reception inward is approximately 63 litres, indicating that tadalafil is distributed into tissues. At therapeutic concentrations 94% of tadalafil bound to plasma proteins.

In healthy persons less than 0.0005% of the dose was found in semen.

In healthy volunteers increased AUC of tadalafil proportionally with the dose in the dose range of 2.5–20 mg Equilibrium concentration is achieved within 5 days when taken daily 1 time per day, with AUC of around 1.6 times greater than when a single dose.

Tadalafil is predominantly metabolized by CYP3A4 to a catechol that undergoes methylation and glukuronirovaniu with the formation of methylcatechol and methylcatechol conjugate with glucuronide, rispettivamente. The main circulating metabolite — methylethanolamine, the concentration of methylcatechol is less than 10% that of the glucuronide. In vitro data suggests that metabolites in the observed concentration does not have pharmacological activity.

Oral clearance of tadalafil is 2.5 l/HR, terminal T1/2 is 17.5 hours in healthy volunteers. Tadalafil is excreted predominantly as metabolites, mainly with feces (di 61% of the dose) and to a lesser extent from the urine (circa 36%).