Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone receptor-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it.
Tamoxifen Citrate pills and injections: what is better to buy?
Tamoxifen Citrate is very popular for preventing estrogen related gynecomastia, resulting from elevated estrogenic levels and is one of the most popular and utilized drug by athletes and bodybuilders worldwide, especially in the post cycle therapy. While using it the Tamoxifen Citrate molecule bound to this receptor, estrogen is blocked from exerting any action, and the anti-estrogenic effect is achieved. Users should know that Tamoxifen acts only as an estrogen antagonist and does not prevent aromatization process. Tamoxifen compounds proved the ability to increase production of follicle stimulating hormone and luteinizing hormone in the human body. It is accomplished by blocking the negative feedback inhibition caused by estrogen at the hypothalamus and pituitary gland.
Tamoxifen Citrate profile
Tamoxifen is given as a pill that is taken by mouth. Typically, the pill is taken once or twice daily. The exact dose and schedule depends on the type of breast cancer being treated and several other doctors. Your doctor will determine the regimen that is best for you. The medicine should be swallowed with water, and can be taken with or without food.
How and when to take Tamoxifen Citrate
Tamoxifen generic plays a role of a barrier that blocks the activity of female hormones. Specific types of carcinoma require the growth of estrogen in organism. This type of carcinoma is known as hormone-positive breast cancer. The cells of the ER-positive (estrogen receptor) breast cancer have receptors. Very often the hormones get attached to these receptors. When the female hormone attaches to the receptor, it provokes the division of the cells. Thus, carcinoma grows in its size.
Tamoxifen Citrate doses, effets and results.
Nolvadex can be purchased upon a doctor’s prescription. Before you start on this medication, it is ideal that you talk to your health care provider about the benefits and risks of taking this drug.
The dosage will differ from patient to patient. Individuals must follow their doctor’s recommendations or the directions given by the pharmacy. In case your dose is different, you must first inform your doctor before changing it. The following is an average dosage when taking this medication in tablet form:
For men and women with breast cancer (adults), 20-40 milligrammes must be taken daily
For reducing breast cancer risk in women for five years (adults), 20 milligrammes are normally taken.
Tamoxifen Citrate side effects
The binding of tamoxifen to estrogen receptors has a profound effect on normal feedback processes. It induces the hypothalamus to sense a falsely high estrogen level, resulting in cessation of ovarian stimulation. In short, it induces an artificial menopause.
Tamoxifen-induced estrogen deprivation causes side effects such as hot flashes in 35% of patients. Other related hypoestrogenic symptoms include night sweats, dryness or excessive discharge from the vagina, memory lapses, depressive symptoms, and reduced libido. 17% of women on tamoxifen report insomnia, while 14% have weight gain. Bone loss and cataracts are other commonly reported side effects.
Tamoxifen Citrate for women: what a lady athlete should know about it.
Not recommended in case of hypersensitivity to the drug, leukopenia, thrombocytopenia, hyperlipidemia, hypercalcemia, cataracts, pregnancy and thrombophlebitis. During treatment it is necessary to monitor the leukocytes, platelets, calcium levels and blood coagulation system indices. In some pre-menopausal women, administering the drug to treat breast cancer may suppress the menstruation process.
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